THE EFFECTS OF LISDEXAMFETAMINE DIMESYLATE ON EATING BEHAVIOUR AND HOMEOSTATIC, REWARD AND COGNITIVE PROCESSES IN WOMEN WITH BINGE-EATING SYMPTOMS: AN EXPERIMENTAL MEDICINE STUDY

Abstract Lisdexamfetamine dimesylate (LDX) is the only drug currently approved by the FDA for the treatment of Binge-Eating Disorder (BED), but little is known about the behavioural mechanisms that underpin the efficacy of LDX in treating BED.We examined the behavioural and neural effects of an acute dose of LDX (50 mg) in 22 women with binge-eatin

The IntelliCage (IC) permits the assessment of the behavior and learning abilities of mice in a social home cage context.To overcome water deprivation as an aversive driver of learning, we developed protocols in which spatial learning is motivated appetitively by the preference of mice for sweetened over plain water.While plain water is available a

Understanding the static nail coupon mechanisms that protect against or limit muscle atrophy in hibernators during prolonged inactivity has important implications for its treatment.We examined whether external factors influence the pathways regulating protein synthesis and degradation, leading to muscle atrophy prevention in Daurian ground squirrel

Abstract Solid tumors are complex entities that actively shape their microenvironment to create a supportive environment for their own growth.Angiogenesis and immune suppression are two key characteristics of this tumor microenvironment.Despite attempts to deplete tumor blood vessels using antiangiogenic drugs, extensive vessel pruning has shown li

Introduction.We present the extremely rare case of a patient with three metachronous osteosarcomas within 22 years without evident pulmonary manifestation of disease 30 years after first diagnosis.Case Presentation.In 1983, a high-grade osteosarcoma of the left distal femur was diagnosed in an 18-year-old Caucasian male.He received rotationplasty a